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Target
Sentrin-specific protease 8
Ligand
BDBM71269
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay
IC50
2450±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM71269
Synonyms:
3-(2,5-dimethoxyanilino)-2H-isoquinolin-1-one | 3-(2,5-dimethoxyanilino)isocarbostyril | 3-[(2,5-dimethoxyphenyl)amino]-2H-isoquinolin-1-one | MLS000541664 | SMR000472265 | cid_16727388
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3
Mol. Mass.:
296.3205
SMILES:
COc1ccc(OC)c(Nc2cc3ccccc3c(=O)[nH]2)c1
Structure:
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