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Target
Sentrin-specific protease 8
Ligand
BDBM76690
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay
IC50
2440±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM76690
Synonyms:
(6E)-4-nitro-6-[[(1-phenyl-4-pyrazolo[3,4-d]pyrimidinyl)hydrazo]methylidene]-1-cyclohexa-2,4-dienone | (6E)-4-nitro-6-[[2-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one | (6E)-4-nitro-6-[[N'-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazino]methylene]cyclohexa-2,4-dien-1-one | MLS001164335 | SMR000539629 | cid_5930611
Type:
Small organic molecule
Emp. Form.:
C18H13N7O3
Mol. Mass.:
375.3409
SMILES:
Oc1ccc(cc1CN=Nc1ncnc2n(ncc12)-c1ccccc1)[N+]([O-])=O |w:9.10|
Structure:
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