Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM76193
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM76193
Synonyms:
(2Z)-2-[2-[2-(3-methoxy-3-oxidanylidene-propylidene)hydrazinyl]-4-oxidanylidene-1,3-thiazol-5-ylidene]ethanoic acid | (2Z)-2-[2-[2-(3-methoxy-3-oxopropylidene)hydrazinyl]-4-oxo-1,3-thiazol-5-ylidene]acetic acid | (2Z)-2-[2-[2-(3-methoxy-3-oxopropylidene)hydrazinyl]-4-oxo-5-thiazolylidene]acetic acid | (2Z)-2-[4-keto-2-[N'-(3-keto-3-methoxy-propylidene)hydrazino]-2-thiazolin-5-ylidene]acetic acid | 3-({5-[1-Carboxy-meth-(Z)-ylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-hydrazono)-propionic acid methyl ester | MLS000777481 | SMR000413875 | cid_16682271
Type:
Small organic molecule
Emp. Form.:
C9H9N3O5S
Mol. Mass.:
271.25
SMILES:
COC(=O)CC=NNC1=NC(=O)C(S1)=CC(O)=O |w:6.6,14.15,t:8|
Structure:
Search PDB for entries with ligand similarity: