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Target
Sentrin-specific protease 6
Ligand
BDBM76568
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay
IC50
849±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 6
Synonyms:
KIAA0797 | SENP6 | SENP6_HUMAN | SSP1 | SUMO-1-specific protease | SUSP1 | Sentrin-specific protease 6 (SENP6)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
126147.68
Organism:
Homo sapiens (Human)
Description:
Q9GZR1
Residue:
1112
Sequence:
MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDEDSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSENTQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRLQGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQTNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKRRKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSNPGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLSSTHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQEDQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
  
Inhibitor
Name:
BDBM76568
Synonyms:
2-Methyl-furan-3-carboxylic acid [1-(4-diethylamino-2-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide | MLS000778052 | N'-[(E)-[4-(diethylamino)-6-keto-cyclohexa-2,4-dien-1-ylidene]methyl]-2-methyl-3-furohydrazide | N'-[(E)-[4-(diethylamino)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]-2-methyl-furan-3-carbohydrazide | N'-[(E)-[4-(diethylamino)-6-oxo-1-cyclohexa-2,4-dienylidene]methyl]-2-methyl-3-furancarbohydrazide | N'-[(E)-[4-(diethylamino)-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]-2-methylfuran-3-carbohydrazide | SMR000414446 | cid_5791416
Type:
Small organic molecule
Emp. Form.:
C17H21N3O3
Mol. Mass.:
315.3669
SMILES:
CCN(CC)c1ccc(C=NNC(=O)c2ccoc2C)c(O)c1 |w:10.10|
Structure:
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