Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM77509
Substrate
n/a
Meas. Tech.
Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3
EC50
>85239±n/a nM
Citation
 PubChem, PC Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3 PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM77509
Synonyms:
2-[2-[5-methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]ethynyl]pyridine | 2-[2-[5-methoxy-2-(4-methoxyphenyl)benzothiophen-3-yl]ethynyl]pyridine | MLS002391662 | SMR001355627 | cid_44142497
Type:
Small organic molecule
Emp. Form.:
C23H17NO2S
Mol. Mass.:
371.452
SMILES:
COc1ccc(cc1)-c1sc2ccc(OC)cc2c1C#Cc1ccccn1
Structure:
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