Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM57572
Substrate
n/a
Meas. Tech.
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
IC50
>39519±n/a nM
Citation
 PubChem, PC Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2010)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM57572
Synonyms:
5-Methyl-3-phenyl-isoxazole-4-carboxylic acid [N'-(2,4-dihydroxy-benzoyl)-hydrazinocarbothioyl]-amide | MLS000590710 | N-[[(2,4-dihydroxybenzoyl)amino]carbamothioyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide | N-[[(2,4-dihydroxybenzoyl)amino]thiocarbamoyl]-5-methyl-3-phenyl-isoxazole-4-carboxamide | N-[[[(2,4-dihydroxyphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]-5-methyl-3-phenyl-4-isoxazolecarboxamide | N-[[[2,4-bis(oxidanyl)phenyl]carbonylamino]carbamothioyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide | SMR000219123 | cid_1883073
Type:
Small organic molecule
Emp. Form.:
C19H16N4O5S
Mol. Mass.:
412.419
SMILES:
Cc1onc(c1C(=O)NC(=S)NNC(=O)c1ccc(O)cc1O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: