Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM77574
Substrate
n/a
Meas. Tech.
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
IC50
73326±n/a nM
Citation
 PubChem, PC Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2010)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM77574
Synonyms:
2-(4-oxo-2-{2-[1-(2-pyridyl)ethylidene]hydrazono}-1,3-thiazolan-5-yl)acetic acid | 2-[4-keto-2-[N'-[1-(2-pyridyl)ethylidene]hydrazino]-2-thiazolin-5-yl]acetic acid | 2-[4-oxidanylidene-2-[2-(1-pyridin-2-ylethylidene)hydrazinyl]-1,3-thiazol-5-yl]ethanoic acid | 2-[4-oxo-2-[2-(1-pyridin-2-ylethylidene)hydrazinyl]-1,3-thiazol-5-yl]acetic acid | 2-[4-oxo-2-[2-[1-(2-pyridinyl)ethylidene]hydrazinyl]-5-thiazolyl]acetic acid | MLS000850805 | SMR000456822 | cid_3322285
Type:
Small organic molecule
Emp. Form.:
C12H12N4O3S
Mol. Mass.:
292.314
SMILES:
CC(N=Nc1nc(O)c(CC(O)=O)s1)c1ccccn1 |w:3.3|
Structure:
Search PDB for entries with ligand similarity: