Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM77626
Substrate
n/a
Meas. Tech.
SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology
IC50
6180±n/a nM
Citation
 PubChem, PC SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology PubChem Bioassay (2010)[AID] 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
TRPC4_MOUSE | Trpc4 | Trrp4 | alternatively spliced Trp4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111587.67
Organism:
Mus musculus
Description:
Q9QUQ5
Residue:
974
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
  
Inhibitor
Name:
BDBM77626
Synonyms:
6-fluoranyl-4-methyl-2-piperidin-1-yl-quinoline;2,2,2-tris(fluoranyl)ethanoic acid | 6-fluoro-4-methyl-2-(1-piperidinyl)quinoline;2,2,2-trifluoroacetic acid | 6-fluoro-4-methyl-2-piperidin-1-ylquinoline;2,2,2-trifluoroacetic acid | 6-fluoro-4-methyl-2-piperidino-quinoline;2,2,2-trifluoroacetic acid | VU0419901-1 | cid_46891902
Type:
Small organic molecule
Emp. Form.:
C15H17FN2
Mol. Mass.:
244.3073
SMILES:
Cc1cc(nc2ccc(F)cc12)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: