Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM55408
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
4530±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM55408
Synonyms:
2-[(E)-2-(5-nitrofuran-2-yl)ethenyl]-3-(3-oxidanylpropyl)quinazolin-4-one | 3-(3-hydroxypropyl)-2-[(E)-2-(5-nitro-2-furanyl)ethenyl]-4-quinazolinone | 3-(3-hydroxypropyl)-2-[(E)-2-(5-nitro-2-furyl)vinyl]quinazolin-4-one | 3-(3-hydroxypropyl)-2-[(E)-2-(5-nitrofuran-2-yl)ethenyl]quinazolin-4-one | 3-(3-hydroxypropyl)-2-[2-(5-nitro-2-furyl)vinyl]-4(3H)-quinazolinone | MLS000535020 | SMR000142456 | cid_5736472
Type:
Small organic molecule
Emp. Form.:
C17H15N3O5
Mol. Mass.:
341.3181
SMILES:
OCCCn1c(\C=C\c2ccc(o2)[N+]([O-])=O)nc2ccccc2c1=O
Structure:
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