Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM66051
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
8630±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM66051
Synonyms:
3-[2,5-bis(oxidanylidene)pyrrol-1-yl]-4-chloranyl-N-(4-methylphenyl)benzamide | 4-chloro-3-(2,5-dioxo-1-pyrrolyl)-N-(4-methylphenyl)benzamide | 4-chloro-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(4-methylphenyl)benzamide | 4-chloro-3-(2,5-dioxopyrrol-1-yl)-N-(4-methylphenyl)benzamide | 4-chloro-3-maleimido-N-(p-tolyl)benzamide | MLS000574219 | SMR000195810 | cid_885550
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O3
Mol. Mass.:
340.76
SMILES:
Cc1ccc(NC(=O)c2ccc(Cl)c(c2)N2C(=O)C=CC2=O)cc1 |c:19|
Structure:
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