Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78263
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
6610±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78263
Synonyms:
4-bromo-N'-[(4-fluorobenzoyl)oxy]benzenecarboximidamide | 4-fluorobenzoic acid [(Z)-[amino-(4-bromophenyl)methylene]amino] ester | 4-fluorobenzoic acid [(Z)-[amino-(4-bromophenyl)methylidene]amino] ester | MLS000683345 | SMR000267701 | [(Z)-[amino-(4-bromophenyl)methylidene]amino] 4-fluorobenzoate | [(Z)-[azanyl-(4-bromophenyl)methylidene]amino] 4-fluoranylbenzoate | cid_5344872
Type:
Small organic molecule
Emp. Form.:
C14H10BrFN2O2
Mol. Mass.:
337.144
SMILES:
NC(=NOC(=O)c1ccc(F)cc1)c1ccc(Br)cc1 |w:2.2|
Structure:
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