Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78391
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
6520±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78391
Synonyms:
MLS001167416 | N-(6-methyl-2-pyridinyl)-5-nitro-2-thiophenecarboxamide | N-(6-methyl-2-pyridyl)-5-nitro-thiophene-2-carboxamide | N-(6-methylpyridin-2-yl)-5-nitro-thiophene-2-carboxamide | N-(6-methylpyridin-2-yl)-5-nitrothiophene-2-carboxamide | SMR000640705 | cid_3662576
Type:
Small organic molecule
Emp. Form.:
C11H9N3O3S
Mol. Mass.:
263.272
SMILES:
Cc1cccc(NC(=O)c2ccc(s2)[N+]([O-])=O)n1
Structure:
Search PDB for entries with ligand similarity: