Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78400
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
7080±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78400
Synonyms:
2-mesyl-5-(2-methylpiperidino)-4-tosyl-thiazole | 4-(4-methylphenyl)sulfonyl-5-(2-methyl-1-piperidinyl)-2-methylsulfonylthiazole | 4-(4-methylphenyl)sulfonyl-5-(2-methylpiperidin-1-yl)-2-methylsulfonyl-1,3-thiazole | MLS001110748 | SMR000624754 | cid_20888666
Type:
Small organic molecule
Emp. Form.:
C17H22N2O4S3
Mol. Mass.:
414.563
SMILES:
CC1CCCCN1c1sc(nc1S(=O)(=O)c1ccc(C)cc1)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: