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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78643
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm
IC50
2312±59 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78643
Synonyms:
2-[2-(4-{3-[(4-chlorobenzyl)oxy]-2-hydroxypropyl}-1-piperazinyl)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione dihydrochloride | 2-[2-[4-[3-(4-chlorobenzyl)oxy-2-hydroxy-propyl]piperazino]ethyl]benzo[de]isoquinoline-1,3-quinone;hydrochloride | 2-[2-[4-[3-[(4-chlorophenyl)methoxy]-2-hydroxypropyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione;hydrochloride | 2-[2-[4-[3-[(4-chlorophenyl)methoxy]-2-hydroxypropyl]piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione;hydrochloride | 2-[2-[4-[3-[(4-chlorophenyl)methoxy]-2-oxidanyl-propyl]piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione;hydrochloride | MLS000571940 | SMR000193958 | cid_11979307
Type:
Small organic molecule
Emp. Form.:
C28H30ClN3O4
Mol. Mass.:
508.009
SMILES:
OC(COCc1ccc(Cl)cc1)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Structure:
Search PDB for entries with ligand similarity: