Reaction Details Report a problem with these data
Target
Perilipin-1
Ligand
BDBM79419
Substrate
n/a
Meas. Tech.
Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain
IC50
2068±n/a nM
Citation
 PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) PubChem Bioassay (2011)[AID] 
Target
Name:
Perilipin-1
Synonyms:
PERI | PLIN | PLIN1 | PLIN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55988.69
Organism:
Homo sapiens (Human)
Description:
gi_223718203
Residue:
522
Sequence:
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS
  
Inhibitor
Name:
BDBM79419
Synonyms:
(4Z)-1-(2-furanylmethyl)-2-methyl-4-[(4-nitrophenyl)methylidene]-5-oxo-3-pyrrolecarboxylic acid methyl ester | (4Z)-1-(2-furfuryl)-5-keto-2-methyl-4-(4-nitrobenzylidene)-2-pyrroline-3-carboxylic acid methyl ester | MLS000674921 | SMR000291966 | cid_2185539 | methyl (4Z)-1-(furan-2-ylmethyl)-2-methyl-4-[(4-nitrophenyl)methylidene]-5-oxidanylidene-pyrrole-3-carboxylate | methyl (4Z)-1-(furan-2-ylmethyl)-2-methyl-4-[(4-nitrophenyl)methylidene]-5-oxopyrrole-3-carboxylate | methyl 1-(2-furylmethyl)-2-methyl-4-(4-nitrobenzylidene)-5-oxo-4,5-dihydro-1H-pyrrole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H16N2O6
Mol. Mass.:
368.3401
SMILES:
COC(=O)C1=C(C)N(Cc2ccco2)C(=O)\C1=C/c1ccc(cc1)[N+]([O-])=O |c:4|
Structure:
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