Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68024
Substrate
n/a
Meas. Tech.
CHOP dose-response primary assay
IC50
450±n/a nM
Citation
 PubChem, PC CHOP dose-response primary assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68024
Synonyms:
2-[2-[(3,4-dimethoxyphenyl)methyl]-1-benzimidazolyl]-N'-[(E)-(4-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]acetohydrazide | 2-[2-[(3,4-dimethoxyphenyl)methyl]benzimidazol-1-yl]-N'-[(E)-(4-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]ethanehydrazide | 2-[2-[(3,4-dimethoxyphenyl)methyl]benzimidazol-1-yl]-N'-[(E)-(4-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | MLS000587847 | N'-[(E)-(6-keto-4-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]-2-(2-veratrylbenzimidazol-1-yl)acetohydrazide | SMR000211867 | [2-(3,4-Dimethoxy-benzyl)-benzoimidazol-1-yl]-acetic acid [1-(2-hydroxy-4-methyl-phenyl)-meth-(E)-ylidene]-hydrazide | cid_5936719
Type:
Small organic molecule
Emp. Form.:
C26H26N4O4
Mol. Mass.:
458.509
SMILES:
COc1ccc(Cc2nc3ccccc3n2CC(=O)NN=Cc2ccc(C)cc2O)cc1OC |w:20.21|
Structure:
Search PDB for entries with ligand similarity: