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Target
Caspase-3
Ligand
BDBM79429
Substrate
n/a
Meas. Tech.
Dose response counterscreen for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-3
EC50
>85318±n/a nM
Citation
 PubChem, PC Dose response counterscreen for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-3 PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM79429
Synonyms:
(2-oxidanylideneoxolan-3-yl) 2-(3,4-dimethoxyphenyl)quinoline-4-carboxylate | (2-oxooxolan-3-yl) 2-(3,4-dimethoxyphenyl)quinoline-4-carboxylate | 2-(3,4-dimethoxyphenyl)-4-quinolinecarboxylic acid (2-oxo-3-oxolanyl) ester | 2-(3,4-dimethoxyphenyl)cinchoninic acid (2-ketotetrahydrofuran-3-yl) ester | MLS000081723 | SMR000062971 | cid_2999765
Type:
Small organic molecule
Emp. Form.:
C22H19NO6
Mol. Mass.:
393.3894
SMILES:
COc1ccc(cc1OC)-c1cc(C(=O)OC2CCOC2=O)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: