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Target
Caspase-7
Ligand
BDBM79436
Substrate
n/a
Meas. Tech.
Dose response assay for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-7
EC50
>85261±n/a nM
Citation
 PubChem, PC Dose response assay for dual activators of procaspase-3 and procaspase-7: Absorbance-based biochemical high throughput screening assay to identify activators of procaspase-7 PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM79436
Synonyms:
1-(4-Chloro-phenyl)-5-(2-methoxy-phenyl)-4,6-dioxo-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester | 1-(4-chlorophenyl)-4,6-diketo-5-(2-methoxyphenyl)-3a,6a-dihydropyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester | 1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,6-dioxo-3a,6a-dihydropyrrolo[3,4-c]pyrazole-3-carboxylic acid methyl ester | MLS000590216 | SMR000219345 | cid_3805981 | methyl 1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,6-bis(oxidanylidene)-3a,6a-dihydropyrrolo[3,4-c]pyrazole-3-carboxylate | methyl 1-(4-chlorophenyl)-5-(2-methoxyphenyl)-4,6-dioxo-3a,6a-dihydropyrrolo[3,4-c]pyrazole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H16ClN3O5
Mol. Mass.:
413.811
SMILES:
COC(=O)c1[nH]n(-c2ccc(Cl)cc2)c2c(O)n(-c3ccccc3OC)c(=O)c12 |(13.99,-5.79,;13.51,-4.33,;12.01,-4.01,;10.98,-5.15,;11.53,-2.54,;12.43,-1.3,;11.53,-.07,;12.01,1.4,;10.98,2.54,;11.46,4.01,;12.96,4.33,;13.44,5.79,;13.99,3.18,;13.51,1.72,;10.07,-.53,;8.61,-.06,;8.13,1.41,;7.7,-1.3,;6.16,-1.3,;5.39,-2.64,;3.85,-2.64,;3.08,-1.3,;3.85,.03,;5.39,.03,;6.16,1.36,;5.39,2.7,;8.61,-2.55,;8.13,-4.02,;10.07,-2.07,)|
Structure:
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