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Target
Beta-adrenergic receptor kinase 1
Ligand
BDBM57870
Substrate
n/a
Meas. Tech.
Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1
EC50
120±n/a nM
Citation
 PubChem, PC Dose Response of inhibitors of GRK2 binding with RNA aptamer, Cherry Pick 1 PubChem Bioassay (2011)[AID] 
Target
Name:
Beta-adrenergic receptor kinase 1
Synonyms:
ADRBK1 | ARBK1_HUMAN | BARK | BARK1 | Beta-ARK-1 | Beta-adrenergic receptor kinase 1 | G-protein coupled receptor kinase 2 | G-protein coupled receptor kinase 2 (GRK2) | GRK2
Type:
Enzyme
Mol. Mass.:
79581.30
Organism:
Homo sapiens (Human)
Description:
P25098
Residue:
689
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLVQRGSANGL
  
Inhibitor
Name:
BDBM57870
Synonyms:
(2Z)-1-ethyl-2-[(1-ethyl-6-methyl-2-quinolin-1-iumyl)methylidene]thieno[3,2-e][1,3]benzothiazole;iodide | (2Z)-1-ethyl-2-[(1-ethyl-6-methyl-quinolin-1-ium-2-yl)methylene]thieno[3,2-e][1,3]benzothiazole;iodide | (2Z)-1-ethyl-2-[(1-ethyl-6-methyl-quinolin-1-ium-2-yl)methylidene]thieno[3,2-e][1,3]benzothiazole;iodide | (2Z)-1-ethyl-2-[(1-ethyl-6-methylquinolin-1-ium-2-yl)methylidene]thieno[3,2-e][1,3]benzothiazole;iodide | 1-ethyl-2-[(Z)-(1-ethylthieno[3,2-e][1,3]benzothiazol-2(1H)-ylidene)methyl]-6-methylquinolinium | MLS000724336 | SMR000305930 | cid_16193285
Type:
Small organic molecule
Emp. Form.:
C24H23N2S2
Mol. Mass.:
403.582
SMILES:
CCN1\C(Sc2ccc3sccc3c12)=C\c1ccc2cc(C)ccc2[n+]1CC
Structure:
Search PDB for entries with ligand similarity: