Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM76940
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
17400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM76940
Synonyms:
5-[(4-chloranyl-3,5-dimethyl-pyrazol-1-yl)methyl]-N-[(4-methylphenyl)methyl]furan-2-carboxamide | 5-[(4-chloro-3,5-dimethyl-1-pyrazolyl)methyl]-N-[(4-methylphenyl)methyl]-2-furancarboxamide | 5-[(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methyl]-N-(4-methylbenzyl)-2-furamide | 5-[(4-chloro-3,5-dimethyl-pyrazol-1-yl)methyl]-N-(4-methylbenzyl)-2-furamide | 5-[(4-chloro-3,5-dimethylpyrazol-1-yl)methyl]-N-[(4-methylphenyl)methyl]furan-2-carboxamide | MLS000085472 | SMR000020407 | cid_3240518
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3O2
Mol. Mass.:
357.834
SMILES:
Cc1nn(Cc2ccc(o2)C(=O)NCc2ccc(C)cc2)c(C)c1Cl
Structure:
Search PDB for entries with ligand similarity: