Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78028
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
2020±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78028
Synonyms:
4-[[2-(4-ethyl-3-keto-morpholin-2-yl)acetyl]amino]benzoic acid ethyl ester | 4-[[2-(4-ethyl-3-oxo-2-morpholinyl)-1-oxoethyl]amino]benzoic acid ethyl ester | MLS000063925 | SMR000076803 | cid_2956109 | ethyl 4-[2-(4-ethyl-3-oxidanylidene-morpholin-2-yl)ethanoylamino]benzoate | ethyl 4-[[2-(4-ethyl-3-oxomorpholin-2-yl)acetyl]amino]benzoate | ethyl 4-{[(4-ethyl-3-oxo-2-morpholinyl)acetyl]amino}benzoate
Type:
Small organic molecule
Emp. Form.:
C17H22N2O5
Mol. Mass.:
334.367
SMILES:
CCOC(=O)c1ccc(NC(=O)CC2OCCN(CC)C2=O)cc1
Structure:
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