Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM54723
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
480±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM54723
Synonyms:
4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoic acid ethyl ester | 4-(2,5-dioxo-1-pyrrolyl)benzoic acid ethyl ester | 4-maleimidobenzoic acid ethyl ester | MLS000067565 | SMR000115866 | cid_286520 | ethyl 4-(2,5-dioxopyrrol-1-yl)benzoate | ethyl 4-[2,5-bis(oxidanylidene)pyrrol-1-yl]benzoate
Type:
Small organic molecule
Emp. Form.:
C13H11NO4
Mol. Mass.:
245.2307
SMILES:
CCOC(=O)c1ccc(cc1)N1C(=O)C=CC1=O |c:15|
Structure:
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