Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM67804
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
2070±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM67804
Synonyms:
(4,5-dibromo-6-oxopyridazin-1-yl)methyl 2-chlorobenzoate | 2-chlorobenzoic acid (4,5-dibromo-6-keto-pyridazin-1-yl)methyl ester | 2-chlorobenzoic acid (4,5-dibromo-6-oxo-1-pyridazinyl)methyl ester | MLS000541286 | SMR000126144 | [4,5-bis(bromanyl)-6-oxidanylidene-pyridazin-1-yl]methyl 2-chloranylbenzoate | [4,5-dibromo-6-oxo-1(6H)-pyridazinyl]methyl 2-chlorobenzenecarboxylate | cid_1474487
Type:
Small organic molecule
Emp. Form.:
C12H7Br2ClN2O3
Mol. Mass.:
422.457
SMILES:
Clc1ccccc1C(=O)OCn1ncc(Br)c(Br)c1=O
Structure:
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