Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78074
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
380±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78074
Synonyms:
2-naphthalenecarboxylic acid [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester | MLS000556016 | SMR000147533 | [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] naphthalene-2-carboxylate | [(Z)-[1-azanyl-2-(4-chlorophenyl)ethylidene]amino] naphthalene-2-carboxylate | cid_9550597 | naphthalene-2-carboxylic acid [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O2
Mol. Mass.:
338.788
SMILES:
NC(Cc1ccc(Cl)cc1)=NOC(=O)c1ccc2ccccc2c1 |w:10.11|
Structure:
Search PDB for entries with ligand similarity: