Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78082
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
15900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78082
Synonyms:
(Z)-3-[2-chloro-5-(trifluoromethyl)anilino]-2-cyano-2-propenethioamide | (Z)-3-[2-chloro-5-(trifluoromethyl)anilino]-2-cyano-thioacrylamide | (Z)-3-[2-chloro-5-(trifluoromethyl)anilino]-2-cyanoprop-2-enethioamide | (Z)-3-[[2-chloranyl-5-(trifluoromethyl)phenyl]amino]-2-cyano-prop-2-enethioamide | 3-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-2-cyano-2-propenethioamide | MLS000533445 | SMR000140883 | cid_1894676
Type:
Small organic molecule
Emp. Form.:
C11H7ClF3N3S
Mol. Mass.:
305.707
SMILES:
NC(=S)C(C=Nc1cc(ccc1Cl)C(F)(F)F)C#N |w:5.5|
Structure:
Search PDB for entries with ligand similarity: