Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM47415
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM47415
Synonyms:
2-ethyl-4-nitro-5-(phenylsulfonyl)-1-propyl-1H-imidazole | 2-ethyl-4-nitro-5-(phenylsulfonyl)-1-propyl-imidazole | 5-(benzenesulfonyl)-2-ethyl-4-nitro-1-propylimidazole | 5-besyl-2-ethyl-4-nitro-1-propyl-imidazole | MLS000545864 | SMR000164045 | cid_901979
Type:
Small organic molecule
Emp. Form.:
C14H17N3O4S
Mol. Mass.:
323.367
SMILES:
CCCn1c(CC)nc(c1S(=O)(=O)c1ccccc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: