Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM50154
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
5550±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM50154
Synonyms:
(3Z)-3-(1H-indol-3-ylmethylene)chroman-2,4-quinone | (3Z)-3-(1H-indol-3-ylmethylidene)-3,4-dihydro-2H-1-benzopyran-2,4-dione | (3Z)-3-(1H-indol-3-ylmethylidene)chromene-2,4-dione | 3-(1H-Indol-3-ylmethylene)-chroman-2,4-dione | MLS000553382 | SMR000175359 | cid_5291977
Type:
Small organic molecule
Emp. Form.:
C18H11NO3
Mol. Mass.:
289.2848
SMILES:
O=C1Oc2ccccc2C(=O)\C1=C\c1c[nH]c2ccccc12
Structure:
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