Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM63271
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
2660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM63271
Synonyms:
5-(4-chloranyl-2-nitro-phenyl)sulfanyl-N-propan-2-yl-1,3,4-thiadiazol-2-amine | 5-(4-chloro-2-nitrophenyl)sulfanyl-N-propan-2-yl-1,3,4-thiadiazol-2-amine | 5-[(4-chloro-2-nitrophenyl)thio]-N-propan-2-yl-1,3,4-thiadiazol-2-amine | MLS000417546 | SMR000264488 | [5-[(4-chloro-2-nitro-phenyl)thio]-1,3,4-thiadiazol-2-yl]-isopropyl-amine | cid_2535936
Type:
Small organic molecule
Emp. Form.:
C11H11ClN4O2S2
Mol. Mass.:
330.814
SMILES:
CC(C)Nc1nnc(Sc2ccc(Cl)cc2[N+]([O-])=O)s1
Structure:
Search PDB for entries with ligand similarity: