Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM53611
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
7770±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM53611
Synonyms:
1-(2-methoxyphenyl)-3-[[5-(3-methylphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]pyrrolidine-2,5-dione | 1-(2-methoxyphenyl)-3-[[5-(3-methylphenyl)-1H-1,2,4-triazol-3-yl]thio]pyrrolidine-2,5-dione | 1-(2-methoxyphenyl)-3-[[5-(m-tolyl)-1H-1,2,4-triazol-3-yl]thio]pyrrolidine-2,5-quinone | 1-(2-methoxyphenyl)-3-{[5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]thio}-2,5-pyrrolidinedione | MLS000626947 | SMR000272088 | cid_2930975
Type:
Small organic molecule
Emp. Form.:
C20H18N4O3S
Mol. Mass.:
394.447
SMILES:
COc1ccccc1-n1c(O)cc(Sc2nnc([nH]2)-c2cccc(C)c2)c1O |(3.08,-4.98,;4.41,-4.21,;5.75,-4.98,;5.75,-6.52,;7.08,-7.29,;8.41,-6.52,;8.41,-4.98,;7.08,-4.21,;7.08,-2.67,;8.33,-1.76,;9.79,-2.24,;7.85,-.3,;6.31,-.3,;5.41,.95,;6.03,2.36,;5.26,3.69,;6.29,4.83,;7.7,4.21,;7.54,2.68,;9.03,4.98,;9.03,6.52,;10.37,7.29,;11.7,6.52,;11.7,4.98,;13.03,4.21,;10.37,4.21,;5.84,-1.76,;4.37,-2.24,)|
Structure:
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