Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78235
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
10900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78235
Synonyms:
1-isopropyl-3-(6,7,8,9-tetrahydrobenzocyclohepten-5-ylideneamino)thiourea | 1-propan-2-yl-3-(6,7,8,9-tetrahydrobenzo[7]annulen-5-ylideneamino)thiourea | MLS000391151 | SMR000260188 | cid_4014580
Type:
Small organic molecule
Emp. Form.:
C15H21N3S
Mol. Mass.:
275.412
SMILES:
CC(C)NC(=S)NN=C1CCCCc2ccccc12 |w:7.6|
Structure:
Search PDB for entries with ligand similarity: