Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78241
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
11400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78241
Synonyms:
(4-chlorobenzyl)-[2-(morpholinomethyl)-5-phenyl-thieno[2,3-d]pyrimidin-4-yl]amine | MLS000418034 | N-[(4-chlorophenyl)methyl]-2-(4-morpholinylmethyl)-5-phenyl-4-thieno[2,3-d]pyrimidinamine | N-[(4-chlorophenyl)methyl]-2-(morpholin-4-ylmethyl)-5-phenyl-thieno[2,3-d]pyrimidin-4-amine | N-[(4-chlorophenyl)methyl]-2-(morpholin-4-ylmethyl)-5-phenylthieno[2,3-d]pyrimidin-4-amine | SMR000264865 | cid_2407107
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4OS
Mol. Mass.:
450.984
SMILES:
Clc1ccc(CNc2nc(CN3CCOCC3)nc3scc(-c4ccccc4)c23)cc1
Structure:
Search PDB for entries with ligand similarity: