Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM65245
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
8730±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM65245
Synonyms:
1-(4-chlorophenyl)-3-[[2-(difluoromethoxy)benzoyl]amino]thiourea | 1-(4-chlorophenyl)-3-[[[2-(difluoromethoxy)phenyl]-oxomethyl]amino]thiourea | 1-[[2-[bis(fluoranyl)methoxy]phenyl]carbonylamino]-3-(4-chlorophenyl)thiourea | MLS000704080 | N-(4-chlorophenyl)-2-[2-(difluoromethoxy)benzoyl]hydrazinecarbothioamide | SMR000228089 | cid_998417
Type:
Small organic molecule
Emp. Form.:
C15H12ClF2N3O2S
Mol. Mass.:
371.789
SMILES:
FC(F)Oc1ccccc1C(=O)NNC(=S)Nc1ccc(Cl)cc1
Structure:
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