Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78270
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
29600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78270
Synonyms:
3-cyclopentylpropanoic acid [(Z)-[amino(phenyl)methylidene]amino] ester | 3-cyclopentylpropionic acid [(Z)-[amino(phenyl)methylene]amino] ester | MLS000672221 | N'-[(3-cyclopentylpropanoyl)oxy]benzenecarboximidamide | SMR000293407 | [(Z)-[amino(phenyl)methylidene]amino] 3-cyclopentylpropanoate | [(Z)-[azanyl(phenyl)methylidene]amino] 3-cyclopentylpropanoate | cid_9587649
Type:
Small organic molecule
Emp. Form.:
C15H20N2O2
Mol. Mass.:
260.3315
SMILES:
NC(=NOC(=O)CCC1CCCC1)c1ccccc1 |w:2.2|
Structure:
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