Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78318
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
7490±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78318
Synonyms:
(E)-2-butenedioic acid O1-ethyl ester O4-[2-(4-nitroanilino)-2-oxoethyl] ester | (E)-but-2-enedioic acid O1-ethyl ester O4-[2-keto-2-(4-nitroanilino)ethyl] ester | 1-O-ethyl 4-O-[2-(4-nitroanilino)-2-oxoethyl] (E)-but-2-enedioate | MLS000516612 | O1-ethyl O4-[2-[(4-nitrophenyl)amino]-2-oxidanylidene-ethyl] (E)-but-2-enedioate | SMR000342718 | cid_6393890
Type:
Small organic molecule
Emp. Form.:
C14H14N2O7
Mol. Mass.:
322.2702
SMILES:
CCOC(=O)\C=C\C(=O)OCC(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
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