Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM68198
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
7420±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM68198
Synonyms:
(3R,3aS,7R,7aS)-2-benzyl-7-ethyl-3-(3-furyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one | (3R,3aS,7R,7aS)-2-benzyl-7-ethyl-3-(furan-3-yl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one | (3R,3aS,7R,7aS)-7-ethyl-3-(3-furanyl)-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one | (3R,3aS,7R,7aS)-7-ethyl-3-(furan-3-yl)-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one | MLS000882833 | SMR000465396 | cid_16746350
Type:
Small organic molecule
Emp. Form.:
C21H23NO2
Mol. Mass.:
321.4128
SMILES:
CC[C@@H]1CC=C[C@H]2[C@H]1C(=O)N(Cc1ccccc1)[C@H]2c1ccoc1 |c:4|
Structure:
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