Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM60841
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
3330±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM60841
Synonyms:
2-propenoic acid [4-(3-oxo-1H-isoindol-2-yl)phenyl] ester | 4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl acrylate | MLS001077205 | SMR000472988 | [4-(3-oxidanylidene-1H-isoindol-2-yl)phenyl] prop-2-enoate | [4-(3-oxo-1H-isoindol-2-yl)phenyl] prop-2-enoate | acrylic acid [4-(1-ketoisoindolin-2-yl)phenyl] ester | cid_870529
Type:
Small organic molecule
Emp. Form.:
C17H13NO3
Mol. Mass.:
279.29
SMILES:
C=CC(=O)Oc1ccc(cc1)N1Cc2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity: