Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78361
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
2460±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78361
Synonyms:
1-(3-Chloro-phenyl)-3-diethylamino-pyrrolidine-2,5-dione | 1-(3-chlorophenyl)-3-(diethylamino)pyrrolidine-2,5-dione | 1-(3-chlorophenyl)-3-(diethylamino)pyrrolidine-2,5-quinone | MLS001203275 | SMR000513830 | cid_2840997
Type:
Small organic molecule
Emp. Form.:
C14H17ClN2O2
Mol. Mass.:
280.75
SMILES:
CCN(CC)c1cc(O)n(c1O)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: