Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78381
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
10700±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78381
Synonyms:
3-(1,3-benzodioxol-5-yl)-4-(1H-indol-5-yl)-5-methyl-1,2-oxazole | 3-(1,3-benzodioxol-5-yl)-4-(1H-indol-5-yl)-5-methyl-isoxazole | 3-(1,3-benzodioxol-5-yl)-4-(1H-indol-5-yl)-5-methylisoxazole | MLS001143151 | SMR000631634 | cid_24761333
Type:
Small organic molecule
Emp. Form.:
C19H14N2O3
Mol. Mass.:
318.3261
SMILES:
Cc1onc(c1-c1ccc2[nH]ccc2c1)-c1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: