Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78394
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
18200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78394
Synonyms:
(4E)-5-bromanyl-2-methoxy-4-[(2Z)-2-(8-oxidanyl-1H-quinolin-2-ylidene)ethylidene]cyclohexa-2,5-dien-1-one | (4E)-5-bromo-4-[(2Z)-2-(8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxy-1-cyclohexa-2,5-dienone | (4E)-5-bromo-4-[(2Z)-2-(8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxy-cyclohexa-2,5-dien-1-one | (4E)-5-bromo-4-[(2Z)-2-(8-hydroxy-1H-quinolin-2-ylidene)ethylidene]-2-methoxycyclohexa-2,5-dien-1-one | 2-[(E)-2-(2-bromo-4-hydroxy-5-methoxyphenyl)vinyl]quinolin-8-ol | MLS001196403 | SMR000556280 | cid_24762041
Type:
Small organic molecule
Emp. Form.:
C18H14BrNO3
Mol. Mass.:
372.213
SMILES:
COc1cc(C=Cc2ccc3cccc(O)c3n2)c(Br)cc1O |w:6.6|
Structure:
Search PDB for entries with ligand similarity: