Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78397
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
19200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78397
Synonyms:
MLS001100610 | SMR000654785 | [2-(4-methyl-1,2,5-oxadiazol-3-yl)-1-pyrrolidinyl]-[5-[[3-(trifluoromethyl)phenoxy]methyl]-3-isoxazolyl]methanone | [2-(4-methyl-1,2,5-oxadiazol-3-yl)pyrrolidin-1-yl]-[5-[[3-(trifluoromethyl)phenoxy]methyl]-1,2-oxazol-3-yl]methanone | [2-(4-methylfurazan-3-yl)pyrrolidino]-[5-[[3-(trifluoromethyl)phenoxy]methyl]isoxazol-3-yl]methanone | cid_24791114
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O4
Mol. Mass.:
422.3579
SMILES:
Cc1nonc1C1CCCN1C(=O)c1cc(COc2cccc(c2)C(F)(F)F)on1
Structure:
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