Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78398
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
5450±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78398
Synonyms:
MLS001105787 | SMR000665769 | [5-[(2-chloranyl-4-fluoranyl-phenoxy)methyl]-1,2-oxazol-3-yl]-(4-pyrazin-2-ylpiperazin-1-yl)methanone | [5-[(2-chloro-4-fluoro-phenoxy)methyl]isoxazol-3-yl]-(4-pyrazin-2-ylpiperazino)methanone | [5-[(2-chloro-4-fluorophenoxy)methyl]-1,2-oxazol-3-yl]-(4-pyrazin-2-ylpiperazin-1-yl)methanone | [5-[(2-chloro-4-fluorophenoxy)methyl]-3-isoxazolyl]-[4-(2-pyrazinyl)-1-piperazinyl]methanone | cid_24791380
Type:
Small organic molecule
Emp. Form.:
C19H17ClFN5O3
Mol. Mass.:
417.821
SMILES:
Fc1ccc(OCc2cc(no2)C(=O)N2CCN(CC2)c2cnccn2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: