Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78421
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
12500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78421
Synonyms:
1-(5-chloranyl-2-methoxy-phenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | 1-(5-chloro-2-methoxy-phenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | 1-(5-chloro-2-methoxyphenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | MLS001224330 | SMR000678476 | cid_17297684
Type:
Small organic molecule
Emp. Form.:
C16H16ClFN2OS
Mol. Mass.:
338.827
SMILES:
COc1ccc(Cl)cc1NC(=S)NCCc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: