Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78422
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
23800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78422
Synonyms:
3-chloranyl-N-[2-[(5-chloranyl-2-methoxy-phenyl)amino]-2-oxidanylidene-ethyl]-N-methyl-adamantane-1-carboxamide | 3-chloro-N-[2-(5-chloro-2-methoxy-anilino)-2-keto-ethyl]-N-methyl-adamantane-1-carboxamide | 3-chloro-N-[2-(5-chloro-2-methoxyanilino)-2-oxoethyl]-N-methyl-1-adamantanecarboxamide | 3-chloro-N-[2-(5-chloro-2-methoxyanilino)-2-oxoethyl]-N-methyladamantane-1-carboxamide | MLS001160795 | SMR000709233 | cid_24687800
Type:
Small organic molecule
Emp. Form.:
C21H26Cl2N2O3
Mol. Mass.:
425.349
SMILES:
[H]C12CC3([H])CC(Cl)(C1)CC(C2)(C3)C(=O)N(C)CC(=O)Nc1cc(Cl)ccc1OC |TLB:7:6:12:1.11.2,8:6:12:1.11.2,8:1:12:6.9.5,THB:2:1:9:3.12.5|
Structure:
Search PDB for entries with ligand similarity: