Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78441
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
12600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78441
Synonyms:
6-bromanyl-1-[(3-fluorophenyl)methyl]-2,2-bis(oxidanylidene)-2,1-benzothiazin-4-one | 6-bromo-1-(3-fluorobenzyl)-2,2-diketo-2,1-benzothiazin-4-one | 6-bromo-1-[(3-fluorophenyl)methyl]-2,2-dioxo-2,1-benzothiazin-4-one | MLS002240618 | SMR001308285 | cid_42628492
Type:
Small organic molecule
Emp. Form.:
C15H11BrFNO3S
Mol. Mass.:
384.22
SMILES:
Fc1cccc(CN2c3ccc(Br)cc3C(=O)CS2(=O)=O)c1
Structure:
Search PDB for entries with ligand similarity: