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Target
Neurotensin receptor type 1
Ligand
BDBM67754
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
17600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM67754
Synonyms:
2,4-diketo-3-[6-keto-6-(4-phenylpiperazino)hexyl]-1H-quinazoline-7-carboxylic acid methyl ester | 2,4-dioxo-3-[6-oxo-6-(4-phenyl-1-piperazinyl)hexyl]-1H-quinazoline-7-carboxylic acid methyl ester | MLS000094633 | SMR000030186 | cid_3240356 | methyl 2,4-bis(oxidanylidene)-3-[6-oxidanylidene-6-(4-phenylpiperazin-1-yl)hexyl]-1H-quinazoline-7-carboxylate | methyl 2,4-dioxo-3-[6-oxo-6-(4-phenylpiperazin-1-yl)hexyl]-1,2,3,4-tetrahydroquinazoline-7-carboxylate | methyl 2,4-dioxo-3-[6-oxo-6-(4-phenylpiperazin-1-yl)hexyl]-1H-quinazoline-7-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H30N4O5
Mol. Mass.:
478.5402
SMILES:
COC(=O)c1ccc2c(c1)[nH]c(=O)n(CCCCCC(=O)N1CCN(CC1)c1ccccc1)c2=O
Structure:
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