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Target
Neurotensin receptor type 1
Ligand
BDBM60842
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
12100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM60842
Synonyms:
3-(4-chlorophenyl)-4-(4-hydroxy-3-methoxybenzylidene)-5(4H)-isoxazolone | 3-(4-chlorophenyl)-4-[(E)-(3-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]-2H-1,2-oxazol-5-one | 3-(4-chlorophenyl)-4-[(E)-(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-2H-isoxazol-5-one | 3-(4-chlorophenyl)-4-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2H-1,2-oxazol-5-one | 3-(4-chlorophenyl)-4-[(E)-(4-keto-3-methoxy-cyclohexa-2,5-dien-1-ylidene)methyl]-3-isoxazolin-5-one | MLS001179179 | SMR000476132 | cid_5337349
Type:
Small organic molecule
Emp. Form.:
C17H12ClNO4
Mol. Mass.:
329.734
SMILES:
COC1=CC(=Cc2c([nH]oc2=O)-c2ccc(Cl)cc2)C=CC1=O |w:5.5,c:21,t:2|
Structure:
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