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Target
Neurotensin receptor type 1
Ligand
BDBM47022
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
9590±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM47022
Synonyms:
4-[[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]amino]-2-(trifluoromethyl)benzonitrile | 4-[[4-(2,4-dihydroxyphenyl)-2-thiazolyl]amino]-2-(trifluoromethyl)benzonitrile | 4-[[4-(2,4-dihydroxyphenyl)thiazol-2-yl]amino]-2-(trifluoromethyl)benzonitrile | 4-[[4-[2,4-bis(oxidanyl)phenyl]-1,3-thiazol-2-yl]amino]-2-(trifluoromethyl)benzenecarbonitrile | ML080 | SR-03000000673 | SR-03000000673-1 | cid_25110544
Type:
Small organic molecule
Emp. Form.:
C17H10F3N3O2S
Mol. Mass.:
377.34
SMILES:
Oc1ccc(-c2csc(Nc3ccc(C#N)c(c3)C(F)(F)F)n2)c(O)c1
Structure:
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