Reaction Details Report a problem with these data
Target
Protein Mdm4
Ligand
BDBM79635
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format
IC50
>79000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay (2011)[AID] 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM79635
Synonyms:
4-[(4-amino-6,7-dimethoxy-2-quinazolinyl)amino]benzoic acid ethyl ester | 4-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)amino]benzoic acid ethyl ester | MLS001199677 | SMR000560127 | cid_15989993 | ethyl 4-[(4-amino-6,7-dimethoxyquinazolin-2-yl)amino]benzoate | ethyl 4-[(4-azanyl-6,7-dimethoxy-quinazolin-2-yl)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4
Mol. Mass.:
368.3865
SMILES:
CCOC(=O)c1ccc(Nc2nc(N)c3cc(OC)c(OC)cc3n2)cc1
Structure:
Search PDB for entries with ligand similarity: