Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77791
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77791
Synonyms:
2-(1-oxidanidylpyridin-1-ium-2-yl)sulfanyl-N-(2-phenoxyphenyl)ethanamide | 2-(1-oxidopyridin-1-ium-2-yl)sulfanyl-N-(2-phenoxyphenyl)acetamide | 2-[(1-oxido-2-pyridin-1-iumyl)thio]-N-(2-phenoxyphenyl)acetamide | 2-[(1-oxidopyridin-1-ium-2-yl)thio]-N-(2-phenoxyphenyl)acetamide | MLS001006036 | SMR000349145 | cid_2342380
Type:
Small organic molecule
Emp. Form.:
C19H16N2O3S
Mol. Mass.:
352.407
SMILES:
[O-][n+]1ccccc1SCC(=O)Nc1ccccc1Oc1ccccc1
Structure:
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