Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77793
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent tim10-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77793
Synonyms:
(2-Pyridin-3-yl-quinazolin-4-yl)-p-tolyl-amine | MLS001029627 | N-(4-methylphenyl)-2-(3-pyridinyl)-4-quinazolinamine | N-(4-methylphenyl)-2-pyridin-3-yl-quinazolin-4-amine | N-(4-methylphenyl)-2-pyridin-3-ylquinazolin-4-amine | SMR000426957 | cid_921932 | p-tolyl-[2-(3-pyridyl)quinazolin-4-yl]amine
Type:
Small organic molecule
Emp. Form.:
C20H16N4
Mol. Mass.:
312.3678
SMILES:
Cc1ccc(Nc2nc(nc3ccccc23)-c2cccnc2)cc1
Structure:
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